Antioxidant α‐mangostin downregulates ATP‐binding cassette transporters in HuT78 cells
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چکیده
منابع مشابه
ATP-binding cassette transporters, atherosclerosis, and inflammation.
Although recent genome-wide association studies have called into question the causal relationship between high-density lipoprotein (HDL) cholesterol levels and cardiovascular disease, ongoing research in animals and cells has produced increasing evidence that cholesterol efflux pathways mediated by ATP-binding cassette (ABC) transporters and HDL suppress atherosclerosis. These differing perspec...
متن کاملDeficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.
OBJECTIVE Plasma high-density lipoproteins have several putative antiatherogenic effects, including preservation of endothelial functions. This is thought to be mediated, in part, by the ability of high-density lipoproteins to promote cholesterol efflux from endothelial cells (ECs). The ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) interact with high-density lipoproteins to prom...
متن کاملATP binding cassette transporters and drug resistance in breast cancer.
Resistance to chemotherapy is a critical issue in the management of breast cancer patients. The nature of clinical drug resistance is likely to be multifactorial. However, in the last decade considerable attention has been dedicated to the role played by membrane transporter proteins belonging to the ATP binding cassette protein superfamily, and in particular by the MDR1 product P-glycoprotein ...
متن کاملATP-binding cassette (ABC) transporters in normal and pathological lung
ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) are highly expressed in bronchial epithelium. This review aims to...
متن کاملStatins modulate the expression profile of ATP-binding cassette transporters in human neuroblastoma cells
Background The development of chemoresistance still is a major problem in cancer therapy. Mainly, impact of chemotherapy is based on the upregulation of ATP-binding cassette (ABC) transporters, which correlates with bad prognosis and less chemotherapeutic success. Previously, we could show that the HMG-CoA reductase inhibitor simvastatin is able to inhibit the most prominent ABC transporter ABC...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.675.17